The genus Klebsiella
The genus Klebsiella encompasses 18 species and 8 subspecies of bacteria, and several uncharacterized taxa. The recently described species Raoultella scottii and Raoultella lignicola should also be considered Klebsiella spp.
Klebsiella spp. are found in many different environments and samples types.
Klebsiella spp. are found in many different environments and samples types.
Klebsiella bacteriophages
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Klebsiella oxytoca species complex
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Publications
McCartney AL, Hoyles L. Host interactions of bioactive molecules produced by Klebsiella spp. Microbiota and Host. 2025. MAH-24-0011. doi: 10.1530/MAH-24-0011.
Dawson SJT, Shibu P, Garnett S, Newberry F, Brook TC, Tijani T, Kujawska M, Hall LJ, McCartney AL, Negus D, Hoyles L. Weberviruses are gut-associated phages that infect Klebsiella spp. FEMS Microbiol Ecol. 2025 Apr 14;101(5):fiaf043. doi: 10.1093/femsec/fiaf043. PMID: 40251011; PMCID: PMC12023860.
Shutt-McCabe J, Shaik KB, Hoyles L, McVicker G. The plasmid-borne hipBA operon of Klebsiella michiganensis encodes a potent plasmid stabilization system. J Appl Microbiol. 2024 Oct 3;135(10):lxae246. doi: 10.1093/jambio/lxae246. PMID: 39304528; PMCID: PMC11487325.
McCartney AL, Hoyles L. The role of Klebsiella populations in preterm infants. Biochem Soc Trans. 2023 Apr 26;51(2):887-896. doi: 10.1042/BST20200325. PMID: 37099394; PMCID: PMC10212511.
Newberry F, Shibu P, Smith-Zaitlik T, Eladawy M, McCartney AL, Hoyles L, Negus D. Lytic bacteriophage vB_KmiS-Kmi2C disrupts biofilms formed by members of the Klebsiella oxytoca complex, and represents a novel virus family and genus. J Appl Microbiol. 2023 Apr 3;134(4):lxad079. doi: 10.1093/jambio/lxad079.
Smith-Zaitlik T, Shibu P, McCartney AL, Foster G, Hoyles L, Negus D. Extended genomic analyses of the broad-host-range phages vB_KmiM-2Di and vB_KmiM-4Dii reveal slopekviruses have highly conserved genomes. Microbiology (Reading). 2022 Sep;168(9). doi: 10.1099/mic.0.001247. PMID: 36156193.
Shibu P, McCuaig F, McCartney AL, Kujawska M, Hall LJ, Hoyles L. Improved molecular characterization of the Klebsiella oxytoca complex reveals the prevalence of the kleboxymycin biosynthetic gene cluster. Microb Genom. 2021 Jun;7(6):000592. doi: 10.1099/mgen.0.000592. PMID: 34142942; PMCID: PMC8461473.
Chen Y, Brook TC, Soe CZ, O'Neill I, Alcon-Giner C, Leelastwattanagul O, Phillips S, Caim S, Clarke P, Hall LJ, Hoyles L. Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors. Microb Genom. 2020 Jun;6(6):e000377. doi: 10.1099/mgen.0.000377. PMID: 32436839; PMCID: PMC7371107.
Herridge WP, Shibu P, O'Shea J, Brook TC, Hoyles L. Bacteriophages of Klebsiella spp., their diversity and potential therapeutic uses. J Med Microbiol. 2020 Feb;69(2):176-194. doi: 10.1099/jmm.0.001141. Epub 2020 Jan 24. PMID: 31976857; PMCID: PMC7431098.
Leggett RM, Alcon-Giner C, Heavens D, Caim S, Brook TC, Kujawska M, Martin S, Peel N, Acford-Palmer H, Hoyles L, Clarke P, Hall LJ, Clark MD. Rapid MinION profiling of preterm microbiota and antimicrobial-resistant pathogens. Nat Microbiol. 2020 Mar;5(3):430-442. doi: 10.1038/s41564-019-0626-z. Epub 2019 Dec 16. PMID: 31844297; PMCID: PMC7044117.
Hoyles L, Murphy J, Neve H, Heller KJ, Turton JF, Mahony J, Sanderson JD, Hudspith B, Gibson GR, McCartney AL, van Sinderen D. Klebsiella pneumoniae subsp. pneumoniae-bacteriophage combination from the caecal effluent of a healthy woman. PeerJ. 2015 Jul 28;3:e1061. doi: 10.7717/peerj.1061. PMID: 26246963; PMCID: PMC4525690.
Dawson SJT, Shibu P, Garnett S, Newberry F, Brook TC, Tijani T, Kujawska M, Hall LJ, McCartney AL, Negus D, Hoyles L. Weberviruses are gut-associated phages that infect Klebsiella spp. FEMS Microbiol Ecol. 2025 Apr 14;101(5):fiaf043. doi: 10.1093/femsec/fiaf043. PMID: 40251011; PMCID: PMC12023860.
Shutt-McCabe J, Shaik KB, Hoyles L, McVicker G. The plasmid-borne hipBA operon of Klebsiella michiganensis encodes a potent plasmid stabilization system. J Appl Microbiol. 2024 Oct 3;135(10):lxae246. doi: 10.1093/jambio/lxae246. PMID: 39304528; PMCID: PMC11487325.
McCartney AL, Hoyles L. The role of Klebsiella populations in preterm infants. Biochem Soc Trans. 2023 Apr 26;51(2):887-896. doi: 10.1042/BST20200325. PMID: 37099394; PMCID: PMC10212511.
Newberry F, Shibu P, Smith-Zaitlik T, Eladawy M, McCartney AL, Hoyles L, Negus D. Lytic bacteriophage vB_KmiS-Kmi2C disrupts biofilms formed by members of the Klebsiella oxytoca complex, and represents a novel virus family and genus. J Appl Microbiol. 2023 Apr 3;134(4):lxad079. doi: 10.1093/jambio/lxad079.
Smith-Zaitlik T, Shibu P, McCartney AL, Foster G, Hoyles L, Negus D. Extended genomic analyses of the broad-host-range phages vB_KmiM-2Di and vB_KmiM-4Dii reveal slopekviruses have highly conserved genomes. Microbiology (Reading). 2022 Sep;168(9). doi: 10.1099/mic.0.001247. PMID: 36156193.
Shibu P, McCuaig F, McCartney AL, Kujawska M, Hall LJ, Hoyles L. Improved molecular characterization of the Klebsiella oxytoca complex reveals the prevalence of the kleboxymycin biosynthetic gene cluster. Microb Genom. 2021 Jun;7(6):000592. doi: 10.1099/mgen.0.000592. PMID: 34142942; PMCID: PMC8461473.
Chen Y, Brook TC, Soe CZ, O'Neill I, Alcon-Giner C, Leelastwattanagul O, Phillips S, Caim S, Clarke P, Hall LJ, Hoyles L. Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors. Microb Genom. 2020 Jun;6(6):e000377. doi: 10.1099/mgen.0.000377. PMID: 32436839; PMCID: PMC7371107.
Herridge WP, Shibu P, O'Shea J, Brook TC, Hoyles L. Bacteriophages of Klebsiella spp., their diversity and potential therapeutic uses. J Med Microbiol. 2020 Feb;69(2):176-194. doi: 10.1099/jmm.0.001141. Epub 2020 Jan 24. PMID: 31976857; PMCID: PMC7431098.
Leggett RM, Alcon-Giner C, Heavens D, Caim S, Brook TC, Kujawska M, Martin S, Peel N, Acford-Palmer H, Hoyles L, Clarke P, Hall LJ, Clark MD. Rapid MinION profiling of preterm microbiota and antimicrobial-resistant pathogens. Nat Microbiol. 2020 Mar;5(3):430-442. doi: 10.1038/s41564-019-0626-z. Epub 2019 Dec 16. PMID: 31844297; PMCID: PMC7044117.
Hoyles L, Murphy J, Neve H, Heller KJ, Turton JF, Mahony J, Sanderson JD, Hudspith B, Gibson GR, McCartney AL, van Sinderen D. Klebsiella pneumoniae subsp. pneumoniae-bacteriophage combination from the caecal effluent of a healthy woman. PeerJ. 2015 Jul 28;3:e1061. doi: 10.7717/peerj.1061. PMID: 26246963; PMCID: PMC4525690.
